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SLC25A15 Human Pre
AMG 8379
Phenylbutazone trimethylgallate (LH150)
Calcium L
A 395
SKF38393
Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Metastasis
good ADMET
Cyclin
Direct effects of minoxidil on epidermal cells in culture PMID 6197493
Ephrin Receptor B4 抗体 (YA4095)（Ephrin Receptor B4 Antibody (YA4095)）
Identification of a high
Computational and in vitro Pharmacodynamics Characterization of 1A
Computational and Experimental Studies Reveal That Thymoquinone Blocks the Entry of Coronaviruses Into In Vitro Cells PMID 33532909
Discovery of 4
Effective biotransformation and detoxification of anthraquinone dye reactive blue 4 by using aerobic bacterial granules PMID 28628882
RBM15 Human Pre
ChTX
Ferroptosis induces detrimental effects in chronic EAE and its implications for progressive MS PMID 37491291
Adrenochrome
BGS 649
Men10376
Triterpenes from Pholiota populnea as Cytotoxic Agents and Chemosensitizers to Overcome Multidrug Resistance of Cancer Cells PMID 35293752
globomycin
Distribution of furamidine analogues in tumor cells influence of the number of positive charges PMID 11985467
photosensitizing
2,3,4,6
Hypoxic and Ras
1
Fluoroaliphatic sulfones a new class of delayed
Design and synthesis of a novel candidate compound NTI
Bovine Stearoyl
structure
Docking study yields four novel inhibitors of the protooncogene Pim
Snap25
Conversion of Olmesartan to Olmesartan Medoxomil, A Prodrug that Improves Intestinal Absorption, Confers Substrate Recognition by OATP2B1 PMID 38485855
Preventive action of proxazole in experimentally induced renal hypertension in rats PMID 5314719
Obesity alters monocyte developmental trajectories to enhance metastasis PMID 37166450
Harpagide from radix scrophulariae attenuated ischemic stroke injury through calcium homeostasis regulation between mitochondria
Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy
ETD001 A novel inhaled ENaC blocker with an extended duration of action in vivo PMID 38851923
Properties and pharmacokinetics of two humanized antibodies specific for L
Ascaris nematodes from pig and human make three antibacterial peptides isolation of cecropin P1 and two ASABF peptides PMID 12737319
ZLN005, a PGC
The galectin
Calycosin promotes axon growth by inhibiting PTPRS and alleviates spinal cord injury PMID 38904846
ciliary body
Exploiting heat shock protein expression to develop a non
m
Narasin, a novel antiviral compound that blocks dengue virus protein expression PMID 22155902
indole
Variations in the C
A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double
MOPS and coxsackievirus B3 stability PMID 27940223
Mcl
Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity PMID 28492230
Histone acetyltransferase 1 is a succinyltransferase for histones and non
Discovery of Highly Potent Liver X Receptor β Agonists PMID 27994765
Druggable growth dependencies and tumor evolution analysis in patient
1,7
hyperuricemic mice
角蛋白 71（KRT71）基因
HY
Smad5 signaling roles in hematopoiesis and osteogenesis PMID 15061132
Comprehensive utilization of in silico approach and in vitro experiment to unveil the molecular mechanisms of mono (2
Pre
A piperidinol
Synthesis of norlignans and in vitro inhibitory activity of antigen
IL
Droxinostat, a Histone Deacetylase Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cell Lines via Activation of the Mitochondrial Pathway and Downregulation of FLIP PMID 26947884
18 1
High
Molecular recognition of a carboxy pyridostatin toward G
Single
Mast cells proliferate in the peri
Specific bonding of puromycin to full
Notch1 抗体 (YA6283)（Notch1 Antibody (YA6283)）
Designing around Structural Alerts in Drug Discovery PMID 31497963
Probiotic Combination of Limosilactobacillus fermentum HF07 and Lactococcus lactis HF08 Targeting Gut Microbiota
GW 6604
RKI
非霍奇金淋巴瘤
n1
Roxibolone
Theliatinib
MK 678
H
ROR2 抗体 (YA4163)（ROR2 Antibody (YA4163)）
SLC2A1 modulator
SOAT1 dysregulation in astrocytes drives Blood
ALDH2 activator 1
Divergent effects of the antiretroviral drugs, dolutegravir, tenofovir alafenamide, and tenofovir disoproxil fumarate, on human adipocyte function PMID 38154544
TCO
SimPLIT Simplified Sample Preparation for Large
CDK9
Zelenirstat 1215011
PF06737007
Honokiol 35354
BIIE
Acid
A new water soluble derivative of 4,5'
Myeloid but not hepatocytic CD38 is a key driver for hepatic ischemia/reperfusion injury PMID 40341132
Deoxyshikonin isolated from Arnebia euchroma inhibits colorectal cancer by down
Dopamine D2 receptor antagonist
Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago
Quinoxaline
C24 (2'(S)
Anti
S
Molecular structure at 1.8 A of mouse liver class pi glutathione S
A Novel mTORC1/2 Inhibitor (MTI
kidney microsomes
The effect of monotropein on alleviating cisplatin
glutathionase system
5
K 5407
D
XSJ
VPA
metabolic breakdown
γ
Autophagy regulates Selumetinib (AZD6244) induced
LASSBio 1359
Deltazinone 1 894554
glutathionase
RSK2
Rogaratinib 1443530
RCA I (Fluorescein)
4,4'
Redox
proper
Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity PMID 30763106
胸腺瘤病毒原癌基因3（Akt3）基因
亮氨酸拉链样转录调节因子 1（LZTR1）基因
TCF7L2
NNS
RNASE2 Human Pre
Acetyl
Unlabeled FXX489 3076330
Identification of a 4
Rezafungin 1396640
MZ 101
L
GSK 729
NSC 19790
MOR
Dentonin
Spin
Aldosterone synthase inhibition cardiorenal protection in animal disease models and translation of hormonal effects to human subjects PMID 25491597
TAS3681, an androgen receptor antagonist, prevents drug resistance driven by aberrant androgen receptor signaling in prostate cancer PMID 38600681
PKCi 蛋白, Human (H114A)
RNASE4 Human Pre
Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E‑BP1 in nasopharyngeal carcinoma cells PMID 29344638
D
UCD74A hydrochloride
Fibrillation and molecular characteristics are coherent with clinical and pathological features of 4
RO5126946
Hypogeic acid (50mg/ml in ethanol) 2416
蛋白激酶 C, theta（Prkcq）基因
溶质载体家族 7 成员 6 反链（SLC7A6OS）基因
Atp2b1
METTL3
Fenazoxine
6′
Annexin A1 inhibition facilitates NLRP3 inflammasome activation in arsenic
Microbial transformation of 20(S)
MCE
UBI (31
Naloxone benzoylhydrazone (NalBzoH)
Pkib Mouse Pre
Anemoside A3
Guavinoside A
TRAF6 Human Pre
GT
HY
RN927C, a Site
Residual phenotypic susceptibility to doravirine in multidrug resistant HIV
ATTO 425 NHS ester 892156
Homogeneity or heterogeneity, the paradox of neurovascular pericytes in the brain PMID 34152032
Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine PMID 2366189
MX106
The hope and hype of ellagic acid and urolithins as ligands of SARS
9,10
HIV Nef
Exposure to bisphenol A induces dysfunction of insulin secretion and apoptosis through the damage of mitochondria in rat insulinoma (INS
Site
Sulfaphenazole
POGLUT 1
Il21r Mouse Pre
Erucin
Desmethylcitalopram hydrochloride 97743
The coumarin component isofraxidin targets the G
meta
Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents PMID 9806339
GLP
Interaction of Mycotoxin Alternariol with Serum Albumin PMID 31083629
PROTAC HMGCR Degrader
Postantibiotic effect and postantibiotic sub
Bufadienolide compounds sensitize human breast cancer cells to TRAIL
Radioimmunoassay of 15
RAP
Guancydine a new antihypertensive agent. Use with quinethazone and guanethidine or propranolol PMID 4565483
Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice PMID 35063750
MCE
WAY
7
Molecular cloning and the involvement of IRE1α
Vitronectin promotes immunothrombotic dysregulation in the venular microvasculature PMID 36845099
Inhibitory effects of Mannich bases of heterocyclic chalcones on NO production by activated RAW 264.7 macrophages and superoxide anion generation and elastase release by activated human neutrophils PMID 21441032
Evogliptin tartrate 1222102
SIRT5 regulates granulosa cell proliferation and apoptosis in polycystic ovarian syndrome via desuccinylation of GLI1 PMID 40481676
(R)
Methyl piperate 6190
Aloisines, a new family of CDK/GSK
Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug
Piperazine
Phase I/II Trial of Labetuzumab Govitecan (Anti
白介素 17 受体 A（IL17RA）基因
C2
4
[Use of dimethothiazine in the prevention of hemicrania] PMID 321991
Aminoadamantanes with persistent in vitro efficacy against H1N1 (2009) influenza A PMID 24793875
Flurbiprofen
Dicationic phenyl
T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment PMID 19915044
Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1
Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells PMID 15615540
GRP20–29, frog 136058
Relative free energy of binding and binding mode calculations of HIV
Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad
Identification and Characterization of a New 7
1
Decreased Glycolysis Due to Lactate Dehydrogenase A N6
G 蛋白亚基γ10（GNG10）基因
Effector activity of decidual CD8+ T lymphocytes in early human pregnancy PMID 16822900
An LXR
AP39, a mitochondria
HEI3090 2377167
GSK256471 1133706
Homologous recombination in DNA repair and DNA damage tolerance PMID 18166982
Clonidine induces calcitonin gene
hsa
TEK
Reduced Haloperidol
GSK3532795 hydrochloride 2023808
Long Noncoding RNA TOB1
Early Noninvasive Metabolic Biomarkers of Mutant IDH Inhibition in Glioma PMID 33668509
5
Development of PROTACs for targeted degradation of oncogenic TRK fusions PMID 40666929
Apafant
Antiepileptogenic effects of borneol in pentylenetetrazole
Preclinical and clinical evaluation of intratumoral injection of an IL
Effect of mono
Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform PMID 26660439
PF
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells PMID 21892174
Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid
Structural design, synthesis and pharmacological evaluation of 4
Intervention of epithelial mesenchymal transition against colon cancer cell growth and metastasis based on SOX21/POU4F2/Hedgehog signaling axis PMID 38992573
Regulation of pericyte metabolic reprogramming restricts the AKI to CKD transition PMID 37230215
Anti
Phenylalanine
Synthesis of minoxidil conjugates and their evaluation as HL
Short
Granulocyte Colony
PGC
Timp4 Rat Pre
Tri(pyridin
Synthesis and antiprotozoal activity of dicationic m
Mouse Immunoglobulin G2b (小鼠免疫球蛋白G2b)
Alantolactone Induced Apoptosis and DNA Damage of Cervical Cancer through ATM/CHK2 Signaling Pathway PMID 38972750
PCTR1 improves pulmonary edema fluid clearance through activating the sodium channel and lymphatic drainage in lipopolysaccharide
The human lactoferrin
G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation PMID 37019194
(S)
Zhizhu Decoction Alleviates Intestinal Barrier Damage via Regulating SIRT1/FoxO1 Signaling Pathway in Slow Transit Constipation Model Mice PMID 36044116
Thymosin β4 inhibits PDGF
Fenmetozole
SYN1143 913376
1,3
Alterations in phosphatidylethanolamine levels affect the generation of Aβ PMID 22023223
Sex
Developmental Hypoxia Enhances Kidney Organoid Complexity and Maturity PMID 40841925
Subchronic dermal application of N,N
Structural optimization on a virtual screening hit of smoothened receptor PMID 30939349
Ethyl maltol enhances copper mediated cytotoxicity in lung epithelial cells PMID 33271249
Safety and Efficacy of Vicriviroc (MK
Cellular receptor for poliovirus molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily PMID 2538245
The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome PMID 20650926
Hypoxanthine Produces Rapid Antidepressant Effects by Suppressing Inflammation in Serum and Hippocampus PMID 39441118
TL1A/TNFSF15 蛋白, Rat (HEK293, His)
Metabolomic study reveals the acute hypotensive effect of S
Triclosan exposure causes abnormal bile acid metabolism through IL
RNA synthesis block by 5, 6
The mechanism of mesna in protection from cisplatin
A Randomized Phase II Study of Anti
Ellagic Acid Enhances Apoptotic Sensitivity of Breast Cancer Cells to γ
Dnttip2 Mouse Pre
Palladium(0) Nanoparticle Formation, Stabilization, and Mechanistic Studies Pd(acac)₂ as a Preferred Precursor, [Bu₄N]₂HPO₄ Stabilizer, plus the Stoichiometry, Kinetics, and Minimal, Four
Thermodynamic description of the effect of the mutation Y49F on human glutathione transferase P1
Dopamine D3 receptor agonist 1
Brain receptor binding characteristics and pharmacokinetic
FAM89A Human Pre
2
New merosesquiterpenes from a Vietnamese marine sponge of Spongia sp. and their biological activities PMID 28558970
CHRM4/AKT/MYCN upregulates interferon alpha
MCE
Comparable efficacies of the antimicrobial peptide human lactoferrin 1
Differentiation of c
A2A Adenosine Receptor as a Potential Therapeutic Target in Cystitis
Endonuclease from Gram
Phosphorylation of human glioma
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc
PD
Americanol A 133838
Intravenous immunoglobulin protects the integrity of the intestinal epithelial barrier and inhibits ferroptosis induced by radiation exposure by activating the mTOR pathway PMID 38518594
Exosomal miRNA
Novel series of tunable µOR modulators with enhanced brain penetration for the treatment of opioid use disorder, pain and neuropsychiatric indications PMID 37414346
3
SNAP
The function of the cytoplasmic dynein light chain PTKM23 in the transport of PTSMAD2 during spermatogenesis in Portunus trituberculatus PMID 38900909
High
Discovery of TAK
A functional SNP rs895819 on pre
IL
Tildacerfont
Saikosaponin B3
MCE
Bisphenol A diglycidyl ether phenol
tRNA 剪接核酸内切酶亚基 54（TSEN54）基因
Synthesis and evaluation of butein derivatives for in vitro and in vivo inflammatory response suppression in lymphedema PMID 32361286
Reduced cell viability and apoptosis induction in human thyroid carcinoma and mesothelioma cells exposed to cidofovir PMID 28223140
Synthesis and anti
Dihydroartemisinin targets ANXA2 to suppress hepatocellular carcinoma angiogenesis through the PI3K/AKT signaling pathway PMID 40834828
Edivoxetine hydrochloride (LY 2216684 hydrochloride)
Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4 PMID 26051217
Targeting the CD40
Pskh1 Mouse Pre
NIK250
Hirtellanines A and B, a pair of isomeric isoflavonoid derivatives from Campylotropis hirtella and their immunosuppressive activities PMID 19481938
PABA/NO
Ephemeranthol A
Isorhamnetin attenuates TNF
Gefitinib
Metabolism of 4
High urea and NaCl carbonylate proteins in renal cells in culture and in vivo, and high urea causes 8
GLP
Cigarette smoke disrupts osteogenic
5'
DBCO
Rociletinib (CO
PD 117519 96392
CRBN ligand
JR
NTRK degrader
Extensive structure
Novel anti
Milnacipran inhibits itch
Cyclic interconversion of vitamin K1 and vitamin K1 2,3
乳酸脱氢酶 B（LDHB）基因
The antimicrobial compound reuterin (3
Hydralazine target from blood vessels to the epigenome PMID 16507100
Neohelmanthicin B 918785
3′
10
7
9
The RNA
Orally active inhibitors of human leukocyte elastase. I. Disposition of L
Anti
L6 cells
LSAMP Human Pre
PAD4
Concanavalin A
TelN Protelomerase
[Cu2(bdc)2(bpy)]n
porto
RTCB Human Pre
Pdgfb
ALK/HDAC
HDSI 18
Wnt pathway activator 2 1360540
Phenmedipham
SMARCA2 ligand
SARS 3CLpro
Nizatidine
Guvacine
ACAP1 Human Pre
NCT 58
BKT300
NEU391
1
Tec
PF
Excavatin G 250293
Paneth cells
ALK kinase activity
Calcium levofolinate
Lotaustralin 1973415
Clenproperol
Lyn
(S,R,S)
antihemorrhagic
2
3,3',3''
( )
The role of α7nAchR and PD
Development and biological evaluation of novel SOS1 inhibitors featuring 5,8
Low intensity pulsed ultrasound ameliorates Adriamycin
Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai PMID 20014777
GJG057 2761767
Antivascular and anti
Ssx2ip
L
MCE
Thiol
Effects of aspirin DL
Protective role of TRPV2 in synaptic plasticity through the ERK1/2
The immune
Xylopine Induces Oxidative Stress and Causes G2/M Phase Arrest, Triggering Caspase
Nirmatrelvir
MARCH8 ubiquitinates and degrades CEMIP to induce colorectal cancer cell ferroptosis through inactivating PI3K/AKT pathway PMID 40107011
MCE
Enantioselective total synthesis of cyathin A3 PMID 17580883
P2Y2R antagonist 1
Simufilam hydrochloride 2480226
Arrhythmogenic effects of beta2
Dodec
Veludacigib 2732902
Lipid 20b 2921586
CCI
Alterporriol B
β
Synthesis and anticancer activity of novel curcumin
Steroid 5alpha
SCC
Hiding in Plain Sight Interleukin
Traf6 Rat Pre
Icam1 Rat Pre
WWOX Human Pre
Darutigenol 5940
C
GNE
Targeting the NLRP3 inflammasome in cochlear macrophages protects against hearing loss in chronic suppurative otitis media PMID 39277762
3’
IDE 2 1136466
Diethyl phosphate
(8R,12R,13R)
Extracellular loops 2 and 4 of GLYT2 are required for N
Glecirasib 2657613
TAT
Calcium
Pizuglanstat hydrate 1584160
YH
Antibacterial activity of lipo
UDP
RH 795
Benzylisatin
Cyclo(Hpro
Emitefur
BMS 875944
STAT3
Single
Optimization and SAR research at the benzoxazole and tetrazole rings of JNJ4796 as new anti
Isobutylamide
CO 1
PDGFC Human Pre
LT 052
Bz423
Cullin
Ace2
AZD4901
LY303870
Fer
PROTAC BTK Degrader
ent
mmu
Circ_0000253 promotes the progression of osteosarcoma via the miR
AT
Folate
Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2
ORG
B16
9
Withacoagin 119539
SR58611
Putrescine as an important source of GABA in the postnatal rat subventricular zone PMID 17395389
BC 010
Xenin
Dalmelitinib 1637658
MS8588 3060519
Zika virus
lipid oxidation
FK 463
TGN 1412
Lasalocid sodium 25999
S119
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